IBT Bioservices Middle Eastern Respiratory Syndrome Corona Virus 2 (MERS-COV-2) Virus Like Particle, Wild Type

IBT Bioservices Middle Eastern Respiratory Syndrome Corona Virus 2 (MERS-COV-2) Virus Like Particle, Wild Type 

Summary

• Middle Eastern Respiratory Syndrome Corona Virus 2 (MERS-CoV-2) Virus Like Particle, Wild Type: hybrid alpha-pseudovirus for MERS-CoV-2 (Ha-MERS-CoV-2) for Wild Type strain.   The hybrid alpha-pseudovirus for MERS-CoV-2 (Ha-MERSCoV-2) is a newly developed MARS-CoV-2 virus-like particle (VLP) that encapsulates an alphavirus-derived RNA genome for rapid report expression (luciferase or GFP) in target cells (Hetrick et al., 2022). Different from commonly used S protein pseudotyped lenti- or vesicular stomatitis virus (VSV)pseudoviruses, Ha-MERS-CoV-2 is assembled with all 4 structural proteins (S, M, N, and E) of MERS-CoV-2, and contains a reporter genome derived from an alphavirusbased vector for rapid (6 hours) and robust expression of reporter genes. The alphavirus vector does not contain any of the structural proteins from the authentic virus and the alpha-pseudovirus particles are single-cycle.
• Formulation & Storage: Store at -80°C.
• Notes & Usage Guidelines:
• Size:
• •60X concentrated 5 x 100 µL
• •1x Conc. 25 x 200uL (~100 wells)
• Reporter: Available with Firefly luciferase, GFP, or RFP
• Applications: • Screening and quantification of anti-coronavirusneutralizing antibodies • Anti-coronavirus drug screening • Quantification of viral mutants’ infectivity • Identification of host co-factors and restriction factors of coronaviruses   Intended for research use only, not for human, therapeutic, or diagnostic applications.

Overview

Properties

• Form: Liquid
• Formulation: Available upon request
• Storage: -80°C
• Concentration: 1X Concentrated

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