IBT Bioservices SARS-COV-2, Virus Like Particles (Ha-Cov2) (Ba.4.6 )

IBT Bioservices SARS-COV-2, Virus Like Particles (Ha-Cov2) (Ba.4.6 )

Summary

• SARS-CoV-2, Virus Like Particles (Ha-CoV2) (BA.4.6 ): hybrid alpha-pseudovirus for SARS-CoV-2 (Ha-CoV2) for BA.4.6 strain The hybrid alpha-pseudovirus for SARS-CoV-2 (Ha-CoV-2) is a newly developed SARS-CoV-2 virus-like particle (VLP) that encapsulates an alphavirus-derived RNA genome for rapid report expression (luciferase or GFP) in target cells (Hetrick et al., 2022). Different from commonly used S protein pseudotyped lenti- or vesicular stomatitis virus (VSV)-pseudoviruses, Ha-CoV-2 is assembled with all 4 structural proteins (S, M, N, and E) of SARS-CoV-2, and contains a reporter genome derived from an alphavirusbased vector for rapid (6 hours) and robust expression of reporter genes. The alphavirus vector does not contain any of the structural proteins from the authentic virus and the alpha-pseudovirus particles are single-cycle. Notes & Usage Guidelines: Spike Mutations: Spike T19I, Spike L24S, Spike del25/27, Spike del69/70, Spike G142D, Spike V213G, Spike G339D, Spike R346T, Spike S371F, Spike S373P, Spike S375F, Spike T376A, Spike D405N, Spike R408S, Spike K417N, Spike N440K, Spike L452R, Spike S477N, Spike T478K, Spike E484A, Spike F486V, Spike Q498R, Spike N501Y, Spike Y505H, Spike D614G, Spike H655Y, Spike N658S, Spike N679K, Spike P681H, Spike N764K, Spike D796Y, Spike Q954H, Spike N969K Size: 25 X 200 µL ~100 wells/96 well plate or 60x Conc. 5 x 100 µL Reporter: Available with Firefly luciferase, GFP, or RFP

Overview

Properties

• Form: Liquid
• Formulation: Available upon request
• Storage: -80°C
• Concentration: 1X Concentrated

MSE Supplies is an authorized distributor of IBT Bioservices products.