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MSE PRO 3-Boc-3-azabicyclo[3.1.0]hexane-6-carboxylic acid– MSE Supplies LLC

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MSE PRO 3-Boc-3-azabicyclo[3.1.0]hexane-6-carboxylic acid, ≥97.0% Purity - MSE Supplies LLC

MSE PRO 3-Boc-3-azabicyclo[3.1.0]hexane-6-carboxylic acid, ≥97.0% Purity

SKU: CM1395

  • $ 36995

MSE PRO™ 3-Boc-3-azabicyclo[3.1.0]hexane-6-carboxylic acid, ≥97.0% Purity

MSE PRO™ 3-Boc-3-azabicyclo[3.1.0]hexane-6-carboxylic acid serves as a valuable synthetic intermediate in the preparation of more complex nitrogen-containing heterocyclic scaffolds and natural product analogs. The presence of the Boc protecting group allows for selective deprotection and further functionalization of the amine, while the carboxylic acid group provides a handle for additional transformations. The bicyclic azabicyclo[3.1.0]hexane core is a privileged structure found in various bioactive natural products and pharmaceutical agents, making it an attractive synthetic target for medicinal chemistry programs.

MSE Supplies offers various N-heterocyclic drug small molecules and other chemical reagents. Please contact us for bulk orders.

Technical Specifications:

CAS No. 1119512-39-8
Chemical name 3-Boc-3-azabicyclo[3.1.0]hexane-6-carboxylic acid
Synonym(s)
  • 3-(tert-Butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid
  • 3-[(2-methylpropan-2-yl)oxycarbonyl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid
Molecular formula C11H17NO4     
Pack size 1 g (CM1395)
Molecular weight 227.26 g/mol
Purity ≥97.0%
Boiling point  356 °C 
Density   1.1276 g/cm3 
pKa 4.56±0.20 (Predicted)
Appearance White to off-white solid 
Storage  Store at room temperature


References:

[1] Han, S. J., Lee, G. B., Kwak, H. J., Pagire, S. H., Kim, J. Y., Pagire, H. S., ... & Ahn, J. H. (2015). Synthesis and Diacylglycerol Acyltransferase‐1 Inhibition of Azabicyclo [3.1. 0] hexane Derivatives. Bulletin of the Korean Chemical Society, 36(6), 1586-1593.

[2] Ajay Kumar, K., Lokanatha Rai, K. M., Vasanth Kumar, G., & Mylarappa, B. N. (2012). A facile route for the synthesis of ethyl N-aryl-2, 6-dioxopiperid-3-ene-4-carboxylates and their biological activity. Int J Pharm Pharm Sci, 4(Suppl 4), 564-568.