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MSE PRO 5-Benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one– MSE Supplies LLC

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MSE PRO 5-Benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one, ≥99.0% Purity - MSE Supplies LLC

MSE PRO 5-Benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one, ≥99.0% Purity

SKU: CM1504

  • $ 30995

MSE PRO™ 5-Benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one, ≥99.0% Purity

MSE PRO™ 5-Benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one features a fused azaspiro ring system containing a strained four-membered cyclobutanone moiety. This rigid and constrained architecture can impart conformational preferences and influence the biological activity of target molecules, making it an attractive building block for drug discovery efforts. The strategic incorporation of the oxime functionality provides a reactive handle for further transformations, such as reductions to amines or condensation reactions to form heterocyclic ring systems.

MSE Supplies offers various N-heterocyclic drug small molecules and other chemical reagents. Please contact us for bulk orders.

Technical Specifications:

CAS No. 129306-06-5
Chemical name 5-Benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one
Synonym(s)
  • (E)-5-benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one
  • (Z)-5-benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one
Molecular formula C13H14N2O2
Pack size 1 g (CM1504)
Molecular weight 230.26 g/mol
Purity 99.97% (HPLC)
Appearance White to light yellow solid 
Boiling point  490.5±45.0 °C (Predicted)
Density  1.34±0.1g/cm3 (Predicted)
Storage  Store at 2-8 °C


References:

[1] Hou, J. Y., Wang, D. Z., Li, F., Yan, Z. Y., Liang, Y. M., & Liu, Y. Q. (2012). Synthesis of 5-azaspiro [2.4] heptan and penta-substituted pyrrole derivatives via Pd-catalyzed intramolecular cyclization reaction of alkynyl carboxamides. Synthetic Communications, 42(7), 1070-1084.

[2] Yao, Y., Fan, W., Li, W., Ma, X., Zhu, L., Xie, X., & Zhang, Z. (2011). Synthesis of (S)-7-amino-5-azaspiro [2.4] heptane via highly enantioselective hydrogenation of protected ethyl 1-(2-aminoaceto) cyclopropanecarboxylates. The Journal of Organic Chemistry, 76(8), 2807-2813.