MSE PRO 5-Bromo-2-(pyrrolidin-1-yl)pyrimidine, ≥99.0% Purity

MSE PRO™ 5-Bromo-2-(pyrrolidin-1-yl)pyrimidine, ≥99.0% Purity

MSE PRO™ 5-Bromo-2-(pyrrolidin-1-yl)pyrimidine serves as a valuable synthetic precursor due to the presence of the reactive bromine substituent and the pyrrolidine ring. The bromine atom can undergo various transition metal-catalyzed cross-coupling reactions, allowing the introduction of diverse functional groups and molecular fragments. The pyrimidine core is a privileged heterocyclic scaffold found in numerous bioactive molecules and natural products. Substitution at the 2-position with the pyrrolidine ring further enhances the potential for biological activity, as this motif is prevalent in many drug candidates and approved therapeutics targeting various disease areas, including cancer, viral infections, and kinase-mediated disorders.

MSE Supplies offers various N-heterocyclic drug small molecules and other chemical reagents. Please contact us for bulk orders.

Technical Specifications:

References:

[1] Bigonah-Rasti, S., Sheikhi-Mohammareh, S., Saadat, K., & Shiri, A. (2022). Novel Tricyclic 2-Alkoxy-8-methyl-6-(pyrrolidin-1-yl)-4 H-[1, 2, 4] triazolo [5, 1-f] purine Derivatives: Synthesis and Characterization. Polycyclic Aromatic Compounds, 42(5), 2644-2654.

[2] Maghamifar, R., Sheikhi-Mohammareh, S., Beyzaei, H., Ebrahimnezhad, Z., & Shiri, A. (2023). Synthesis and antimicrobial/antioxidant evaluation of novel pyrimidine-based derivatives with pendant pyrazoles using vinamidinum salts. Journal of the Iranian Chemical Society, 20(9), 2297-2305.