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MSE PRO tBu- 4-(CH2NH2)-5-oxa-2-azabicyclo[2.2.1]heptane-2-carboxylate– MSE Supplies LLC

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MSE PRO tert-Butyl 4-(aminomethyl)-5-oxa-2-azabicyclo[2.2.1]heptane-2-carboxylate, ≥95.0% Purity - MSE Supplies LLC

MSE PRO tert-Butyl 4-(aminomethyl)-5-oxa-2-azabicyclo[2.2.1]heptane-2-carboxylate, ≥95.0% Purity

SKU: CM1394

  • $ 79995

MSE PRO™ tert-Butyl 4-(aminomethyl)-5-oxa-2-azabicyclo[2.2.1]heptane-2-carboxylate, ≥95.0% Purity

MSE PRO™ tert-Butyl 4-(aminomethyl)-5-oxa-2-azabicyclo[2.2.1]heptane-2-carboxylate is an organic compound containing a bicyclic ring system fused with an oxazine ring and a protected amine functionality. The core structure consists of a bridged bicyclic system with a nitrogen atom and an oxygen atom forming a five-membered oxazine ring. The nitrogen atom is further substituted with a carbamate protecting group, tert-butyloxycarbonyl (Boc), and a primary aminomethyl group. The bicyclic oxazine core is a privileged structure found in various bioactive natural products and pharmaceutical agents, making it an attractive synthetic target for medicinal chemistry programs.

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Technical Specifications:

CAS No. 1357351-98-4
Chemical name tert-Butyl 4-(aminomethyl)-5-oxa-2-azabicyclo[2.2.1]heptane-2-carboxylate
Synonym(s)
  • 1-Aminomethyl-2-Oxa-5-Aza-Bicyclo[2.2.1]Heptane-5-Carboxylic Acid Tert-Butyl Ester
  • tert-Butyl 1-(aminomethyl)-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate
Molecular formula C11H20N2O3     
Pack size 250 mg (CM1394)
Molecular weight 228.29 g/mol
Purity ≥95.0%
Boiling point  321.0±27.0 °C (Predicted)
Density   1.176±0.06 g/cm3 (Predicted)
pKa 10.13±0.29 (Predicted)
Appearance White to off-white solid 
Storage  2-8°C, protect from light


References:

[1] Garsi, J. B., Guggari, S., Deis, T., Ma, M., Hocine, S., & Hanessian, S. (2022). 2-Oxa-5-azabicyclo [2.2. 1] heptane as a Platform for Functional Diversity: Synthesis of Backbone-Constrained γ-Amino Acid Analogues. The Journal of Organic Chemistry, 87(16), 11261-11273.

[2] Kou, B., Zhu, W., Liu, H., Shen, H. C., Wu, J., & Hu, T. (2017). Synthesis of bridged bicyclic morpholine amino acids as compact modules for medicinal chemistry. Chemistry Letters, 46(4), 566-568.