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PMS2 Monoclonal Antibody Stored at -20°C– MSE Supplies LLC
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PMS2 Monoclonal Antibody Stored at -20°C

PMS2 Monoclonal Antibody Stored at -20°C

SKU: ELAB6729-M-0.1

  • $ 53395



PMS2 Monoclonal Antibody Stored at -20°C

 

Product Details

Host Mouse
Reactivity Human
Applications IHC-P
Synonyms PMS2
Cellular Localization nucleus
Tissue Specificity Colon cancer
Storage The concentrated should be stored at -20°C protecting from light,Valid for 12 months.
Shipping Ice bag

 

Background

PMS2 is a 96kDa mismatch repair protein that forms a heterodimer with MLH1 protein and is then activated in the presence of ATP. This complex coordinates the binding of other proteins that repair DNA errors that occur during cell division. Loss of PMS2 expression in tumor cells helped to identify hMLH1 mutation vectors and to determine whether they were suitable for mutational analysis. PMS2 defects are responsible for a small but significant proportion of colorectal cancers and a large proportion of tumors with microsatellite instability. PMS2 is associated with cases of the dominant genetic disease hereditary nonpolyposis colon cancer (HNPCC) and is commonly used in cancer studies together with MLH1, MSH2 and MSH6.