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Recombinant Human Activin RIIA/ACVR2A Protein (His Tag)
SKU: PKSH033783-50
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Recombinant Human Activin RIIA/ACVR2A Protein (His Tag)
| SKU # | PKSH033783 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | ACTR-IIA, ACTRII, ACTRIIA, ACVR2, ACVR2A, Activin Receptor Type IIA, Activin Receptor Type-2A |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ala20-Pro134 |
| Accession | P27037 |
| Calculated Molecular Weight | 14.4 kDa |
| Observed Molecular Weight | 28-38 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, 10% Glycerol, 5% Trealose, pH7.4. |
| Reconstitution | Not Applicable |
Background
Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins; composed of a ligand-binding extracellular domain with cysteine-rich region; a transmembrane domain; and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding; resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.