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Recombinant Human AIF1 Protein (His Tag)
SKU: PDEH100002-100
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Recombinant Human AIF1 Protein (His Tag)
| SKU # | PDEH100002 |
| Expression Host | E. coli |
Description
| Synonyms | Allograft Inflammatory Factor 1;AIF-1;Ionized Calcium-Binding Adapter Molecule 1;Protein G1;AIF1;G1;IBA1 |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Ser2-Pro147 |
| Accession | P55008 |
| Mol_Mass | 17.7 kDa |
| AP_Mol_Mass | 16 kDa |
| Tag | C-His |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Allograft Inflammatory Factor 1 (AIF1) contains two EF-hand domains and exists as a homodimer. AIF1 can be detected in T-lymphocytes and peripheral blood mononuclear cells. AIF1 functions as actin-binding protein that enhances membrane ruffling and RAC activation and can enhance the actin-bundling activity of LCP1. In addition, AIF1 plays a role in RAC signaling and in phagocytosis and may also in macrophage activation and function. AIF1 promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes and plays a role in vascular inflammation.