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Recombinant Human Apolipoprotein C-II/APOC2 Protein (His Tag)
SKU: PKSH032084-50
Recombinant Human Apolipoprotein C-II/APOC2 Protein (His Tag)
| SKU # | PKSH032084 |
| Expression Host | E.coli |
Description
| Synonyms | APC2 and APOC2, Apolipoprotein C-II, Apolipoprotein C2 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Thr23-Glu101 |
| Accession | AAP35354.1 |
| Calculated Molecular Weight | 10.0 kDa |
| Observed Molecular Weight | 14 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH 7.4. |
| Reconstitution | Not Applicable |
Background
APOC2 activates the lipoprotein lipase in capillaries, which hydrolyzes triglycerides and thus provides free fatty acids for cells. APOC2 is component of the very low density lipoprotein (VLDL) fraction in plasma. It is also an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. Defects in APOC2 are the cause of hyperlipoproteinemia type 1B (HLPP1B) which characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.