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Recombinant Human ASGR1/ASGPR1 Protein (His Tag)
SKU: PKSH033403-50
Recombinant Human ASGR1/ASGPR1 Protein (His Tag)
| SKU # | PKSH033403 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | ASGP-R 1, ASGPR 1, ASGR1, Asialoglycoprotein Receptor 1, C-Type Lectin Domain Family 4 Member H1, CLEC4H1, HL-1, Hepatic Lectin H1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gln62-Ile291 |
| Accession | P07306 |
| Calculated Molecular Weight | 27.4 kDa |
| Observed Molecular Weight | 34-48 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Asialoglycoprotein Receptor 1 (ASGPR1) is an endocytic recycling receptor; belongs to the long-form subfamily of the C-type/Ca2+-dependent lectin family. ASGPR consists of two noncovalently-linked subnits; ASGPR1 and ASGPR2. ASGPR1 mediates the endocytosis of plasma glycoproteins; recognizes terminal galactose and N-acetylgalactosamine units. When the ligand binds to to ASGPR1; results in the complex is internalized and transported to a sorting organelle; then ASGPR1 and ligand can be disassociated; ASGPR1 returns to the cell membrane surface.