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Recombinant Human ATG4A Protein (His Tag)
SKU: PKSH032099-50
Recombinant Human ATG4A Protein (His Tag)
| SKU # | PKSH032099 |
| Expression Host | E.coli |
Description
| Synonyms | APG4A, ATG4A, AUT-Like 2 Cysteine Endopeptidase, AUTL2, Autophagin-2, Autophagy-Related Cysteine Endopeptidase 2, Autophagy-Related Protein 4 Homolog A, Cysteine Protease ATG4A, hAPG4A |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Val398 |
| Accession | Q8WYN0 |
| Calculated Molecular Weight | 47.5 kDa |
| Observed Molecular Weight | 40-55 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 80 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
| Reconstitution | Not Applicable |
Background
Cysteine Protease ATG4A (ATG4A) is a cytoplasmic protein that belongs to the peptidase C54 family. ATG4A is widely expressed in many tissues at a low level, but the highest expression is observed in skeletal muscle and brain. ATG4A is a cysteine protease required for autophagy; it cleaves the C-terminal part of MAP1LC3, GABARAPL2 or GABARAP. ATG4A is inhibited by N-ethylmaleimide. It is suggested that ATG4A has a significant role in suppressing various cancers.