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Recombinant Human BCMA/TNFRSF17 (C-Fc-Avi) Biotinylated
SKU: PKSH033857-100
Recombinant Human BCMA/TNFRSF17 (C-Fc-Avi) Biotinylated
| SKU # | PKSH033857 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | B-cell maturation protein, CD269, TNFRSF17, Tumor necrosis factor receptor superfamily member 17 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met1-Ala54 |
| Accession | Q02223 |
| Calculated Molecular Weight | 34.6 kDa |
| Observed Molecular Weight | 38-45 kDa |
| Tag | C-Fc-Avi |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 85 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
B cell maturation protein (BCMA) is a type III membrane protein which belongs to the TNF receptor superfamily (TNFRSF17). BCMA contains one extracellular cysteine rich domain, as well as TACI. Human BCMA is a 184 amino acid (aa) protein consisting of a 54 aa extracellular domain, a 23 aa transmembrane domain, and a 107 aa intracellular domain. Mouse and human BCMA share 62% amino acid identity. BCMA is mainly expressed in immune organs and mature B cell lines. BCMA appears to be localized to the Golgi compartment. BCMA may play an important role in B cell development, function and regulation.