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Recombinant Human BLVRA Protein (His Tag)
SKU: PKSH032118-50
Recombinant Human BLVRA Protein (His Tag)
| SKU # | PKSH032118 |
| Expression Host | E.coli |
Description
| Synonyms | BLVR, BLVRA, BVR, BVR A, Biliverdin reductase A, Biliverdin-IX alpha-reductase |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Glu6-Ser294 |
| Accession | P53004 |
| Calculated Molecular Weight | 33.8 kDa |
| Observed Molecular Weight | 35-45 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 50% Glycerol, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Human Biliverdin reductase A (BLVRA) is belonged to the Gfo/Idh/MocA family and Biliverdin reductase subfamily. BLVRA is an enzyme that in humans is encoded by the BLVRA gene. BLVRA plays an important role in reducing the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. BLVRA acts on biliverdin by reducing its double-bond between the pyrrole rings into a single-bond. It accomplishes this using NADPH + H+ as an electron donor, forming bilirubin and NADP+ as products.