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Recombinant Human CAMK4/CaMKIV Protein (GST Tag)– MSE Supplies LLC

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Recombinant Human CAMK4/CaMKIV Protein (GST Tag)

SKU: PKSH031495-50

  • $ 43795



Recombinant Human CAMK4/CaMKIV Protein (GST Tag)

 

SKU # PKSH031495
Expression Host Baculovirus-Insect Cells

 

 

Description

Synonyms CaMK-GR, CaMKIV, IV, caMK
Species Human
Expression Host Baculovirus-Insect Cells
Sequence Met 1-Tyr 473
Accession NP_001735.1
Calculated Molecular Weight 79.0 kDa
Observed Molecular Weight 100 kDa
Tag N-GST
Bio-activity Not validated for activity
  

 

Properties

Purity > 82 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile 50mM Tris, 100mM NaCl, 0.5mM PMSF, pH 8.0
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

Ca2+/ calmodulin-dependent protein kinase 4 (CAMKⅣ) belongs to the serine/threonine protein kinase family, and to the Ca2+/calmodulin-dependent protein kinase subfamily which is widely recognized as an essential enzyme implicated in the phophoinositide amplification cascade. Ca2+/calmodulin dependent protein kinase (CAMK) can be activated by the introcellular increased Ca2+ and then apt to combine with the target protein. Ca2+/ calmodulin-dependent protein kinase 4 (CAMKⅣ) is a multifunctional CaM-dependent kinase protein with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. All of the isforms of this family, including myosin light chain kinase, phosphorylase kinase, CaMK1, CaMKⅢ and CaMKⅣ have EF-hand structure.