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Recombinant Human Carbonic Anhydrase 5B/CA5B Protein (His Tag)
SKU: PKSH032163-50
Recombinant Human Carbonic Anhydrase 5B/CA5B Protein (His Tag)
| SKU # | PKSH032163 |
| Expression Host | E.coli |
Description
| Synonyms | CA-VB, CA5B, Carbonate Dehydratase VB, Carbonic Anhydrase 5B Mitochondrial, Carbonic Anhydrase VB |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Cys34-Pro317 |
| Accession | Q9Y2D0 |
| Calculated Molecular Weight | 33.8 kDa |
| Observed Molecular Weight | 33 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Carbonic Anhydrase 5B (CA5B) is a member of alpha-carbonic anhydrase family (CAs) that catalyze the reversible hydration of carbon dioxide. CAs is associated with many biological processes; including calcification; respiration; bone resorption; acid-base balance and the formation of aqueous humor. CA5B is highly expressed in heart; pancreas; kidney; placenta; lung; and skeletal muscle; but it is restricted to the liver. CA5B is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA; CA-VA. CA5B is inhibited by coumarins; sulfonamide derivatives such as acetazolamide (AZA); saccharin; and Foscarnet.