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Recombinant Human Cathepsin L2/CTSL2 Protein (His Tag)
SKU: PKSH032183-50
Recombinant Human Cathepsin L2/CTSL2 Protein (His Tag)
| SKU # | PKSH032183 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CATL2, CTSL2, CTSU, CTSV, Cathepsin L2, Cathepsin U, Cathepsin V |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Val18-Val334 |
| Accession | O60911 |
| Calculated Molecular Weight | 36.7 kDa |
| Observed Molecular Weight | 33-43 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, 5% Trehalose, 5% Mannitol, 0.01% Tween 80, pH5.5. |
| Reconstitution | Not Applicable |
Background
Cathepsin L2 belongs to the Peptidase C1 family. Cathepsin L2 can be autocatalytically convertedto the mature form as a proenzyme in lysosomes at pH=7.0. Cathepsin L2 cannot be expressed in normal mammary gland, colon and peritumoral tissue, but it can be expressed in breast carcinomas and colorectal tissues. These suggeats Cathepsin L2 may play a role in tumor processes. Cathepsin L2 is specifically expressed in the testis, thymus, and corneal epithelium.