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Recombinant Human CD16b/FCGR3B Protein, Biotinylated (Active)
SKU: PKSH030308-100
Recombinant Human CD16b/FCGR3B Protein, Biotinylated (Active)
| SKU # | PKSH030308 |
| Expression Host | E.coli |
Description
| Synonyms | CD16b and FCGR6B, FCG3, FCGR3, FCRIII, FCRIIIb, Fc-gamma RIII-beta, FcR-10, IgG Fc receptor III-1, Low affinity immunoglobulin gamma Fc region receptor III-B |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 18-Gly 193 |
| Accession | O75015-1 |
| Calculated Molecular Weight | 20.0 kDa |
| Tag | None |
| Bio-activity | 1. Measured by its ability to bind human IgG1 in a functional ELISA. 2. Labeling ratio of biotin to protein: 5. 51. |
| Bio-activity | Measured by its ability to cleave the fluorogenic peptide substrate BocVPRAMC. The specific activity is > 400pmoles/min/μg |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Low affinity immunoglobulin gamma Fc region receptor III-B; also known as Fc-gamma RIII-beta; FcR-10; IgG Fc receptor III-1; FCG3; FCGR3; CD16b and FCGR3B. FCGR3B is a GPI-anchor membrane protein and contains two Ig-like C2 type domains. FCGR3B can be expressed in orphonuclear leukocytes and stimulated eosinophils. FCGR3B can interact with INPP5D/SHIP1. FCGR3B localizes in the FCGR gene cluster is a CN polymorphic gene involved in the recruitment of polymorphonuclear neutrophils to sites of inflammation and their activation. FCGR3B may serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.