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Recombinant Human CD226/DNAM-1 Protein (His Tag)(Active)
SKU: PKSH031523-100
Recombinant Human CD226/DNAM-1 Protein (His Tag)(Active)
| SKU # | PKSH031523 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | DNAM-1, DNAM1, PTA1, TLiSA1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Asn 247 |
| Accession | NP_006557.2 |
| Calculated Molecular Weight | 27.6 kDa |
| Observed Molecular Weight | 40-50 kDa |
| Tag | C-His |
| Bio-activity | Immobilized human CD226 at 2 μg/ml (100 μl/well) can bind human CD112 with a linear ranger of 6. 4-800 ng/ml. |
Properties
| Purity | > 97 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD226; also known as PTA1 or DNAM-1; is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set. High rate of CD226 (Cluster of Differentiation 226) is found on the surface of natural killer cells; platelets; monocytes and a subset of T cells. CD226 have binding sites with CD112 and CD155 and mediate cellular adhesion to other cells containing its ligands.