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Recombinant Human CD27/TNFRSF7 Protein (Fc & His Tag)
SKU: PKSH032210-50
Recombinant Human CD27/TNFRSF7 Protein (Fc & His Tag)
| SKU # | PKSH032210 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | S152, S152. LPFS2, S152.LPFS2, T14, TNFRSF7, Tp55 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Thr 21-Ile192 |
| Accession | P26842 |
| Calculated Molecular Weight | 47.2 kDa |
| Observed Molecular Weight | 60 kDa |
| Tag | C-Fc-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
CD27 antigen is also known as CD27L receptor; T-cell activation antigen CD27; Tumor necrosis factor receptor superfamily member 7; T14 and TNFRSF7. In humans; it is encoded by the CD27 gene. CD27 is a single-pass type I membrane protein with 3 TNFR-Cys repeats. It is a member of the TNF-receptor superfamily and is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70; and plays a key role in regulating B-cell activation and immunoglobulin synthesis. It plays a role in survival of activated T-cells and apoptosis through association with SIVA1.