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Recombinant Human CD44 Protein (Fc Tag)
SKU: PKSH032219-50
Recombinant Human CD44 Protein (Fc Tag)
| SKU # | PKSH032219 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CDW44, CSPG8, ECMR-III, Epican, Extracellular Matrix Receptor III, GP90 Lymphocyte Homing/Adhesion Receptor, HCELL, HUTCH-I, Heparan Sulfate Proteoglycan, Hermes Antigen, Hyaluronate Receptor, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, Phagocytic Glycoprotein |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gln21-Pro220 |
| Accession | P16070 |
| Calculated Molecular Weight | 49.2 kDa |
| Observed Molecular Weight | 75-95 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
CD44 is a cell-surface receptor for hyaluronic acid and also interacts with other ligands; such as osteopontin; collagens; and matrix metalloproteinases. A large number of CD44 isoforms can be generated by the insertion of different combinations of at least nine exons. Increased CD44 antigen is associated with relapses in non-small cell lung cancers. Furthermore; an increasing quantity of evidence suggests that CD44 has various functions related to inflammatory disease. CD44 deficiency induces severe liver injury. CD44-hyaluronate mediates in lymphocyte T and monocyte adhesion to the endothelium; stimulates proinflammatory cytokine release from macrophages and participates in dedifferentiation phenotype of smooth muscle cells from contractile state to synthetic one.