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Recombinant Human CD89/FCAR Protein (His Tag)(Active)– MSE Supplies LLC

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Recombinant Human CD89/FCAR Protein (His Tag)(Active)

SKU: PKSH031620-100

  • $ 65895



Recombinant Human CD89/FCAR Protein (His Tag)(Active)

 

SKU # PKSH031620
Expression Host HEK293 Cells

 

 

Description

Synonyms CD89, CTB-61M7.2, FCAR, FcalphaRI, IgA Fc Receptor, Immunoglobulin Alpha Fc Receptor, XXbac-BPG230H20.5
Species Human
Expression Host HEK293 Cells
Sequence Met 1-Asn 227
Accession NP_001991.1
Calculated Molecular Weight 25 kDa
Observed Molecular Weight 45.7 kDa
Tag C-His
Bio-activity Measured by its ability to bind human IgA in functional Elisa.
  

 

Properties

Purity > 97 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

FCAR, also called FcαRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.