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Recombinant Human CDKN2C Protein (His Tag)– MSE Supplies LLC

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Recombinant Human CDKN2C Protein (His Tag)

SKU: PKSH032310-50

  • $ 47095



Recombinant Human CDKN2C Protein (His Tag)

 

SKU # PKSH032310
Expression Host E.coli

 

 

Description

Synonyms CDKN2C, CDKN6, Cyclin-Dependent Kinase 4 Inhibitor C, Cyclin-Dependent Kinase 6 Inhibitor, p18-INK4c, p18-INK6
Species Human
Expression Host E.coli
Sequence Met 1-Gln168
Accession P42773
Calculated Molecular Weight 20.3 kDa
Observed Molecular Weight 17 kDa
Tag N-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 8.0.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

Cyclin-Dependent Kinase 4 Inhibitor C (CDKN2C) is a member of the INK4 family of cyclin dependent kinase inhibitors. CDKN2C contains 4 ANK repeats and interacts with CDK4 or CDK6. Highest levels of CDKN2C can be found in skeletal muscle, pancreas, and heart. CDKN2C inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB and prevent the activation of the CDK kinases. Studies have been shown the roles of CDKN2C gene in regulating spermatogenesis, as well as in suppressing tumorigenesis.