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Recombinant Human Coagulation Factor IX/F9 Protein (His Tag)(Active)
SKU: PKSH031109-50
Recombinant Human Coagulation Factor IX/F9 Protein (His Tag)(Active)
| SKU # | PKSH031109 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Christmas factor, Coagulation factor 9, Coagulation factor IX, Coagulation factor IXa heavy chain, Coagulation factor IXa light chain, F9, FIX, HEMB, P19, PTC, Plasma thromboplastin component, THPH8 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Thr 461 |
| Accession | AAB59620.1 |
| Calculated Molecular Weight | 50.0 kDa |
| Observed Molecular Weight | 60-80 kDa |
| Tag | C-His |
| Bio-activity | Measured by its ability to cleave the peptide substrate, Z-D-Arg-Gly-Arg-pNA. The specific activity is > 20pmols/min/ug. |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Coagulation factor IX, also known as Christmas factor, Plasma thromboplastin component and PTC, is a secreted protein which belongs to the peptidase S1 family. Coagulation factor IX / F9 contains two EGF-like domains, one Gla (gamma-carboxy-glutamate) domain and one peptidase S1 domain. Coagulation factor IX / F9 is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca2+ons, phospholipids, and factor VIIIa. Defects in Coagulation factor IX / F9 are the cause of thrombophilia due to factor IX defect which is a hemostatic disorder characterized by a tendency to thrombosis. Defects in Coagulation factor IX / F9 are also the cause of recessive X-linked hemophilia B ( HEMB ) which also known as Christmas disease.