Total Price: $0.00
Contact Information
Recombinant Human CSF2RA/GM-CSFR Protein (His Tag)(Active)
SKU: PKSH033281-50
Recombinant Human CSF2RA/GM-CSFR Protein (His Tag)(Active)
| SKU # | PKSH033281 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD116, CDw116, CSF2R, CSF2RA, CSF2RY, GM-CSF-R-Alpha, GMCSFR-Alpha, GMR-Alpha, Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Glu23-Gly320 |
| Accession | P15509 |
| Calculated Molecular Weight | 35.5 kDa |
| Observed Molecular Weight | 60 kDa |
| Tag | C-His |
| Bio-activity | Measured by its ability to inhibit GM-CSF-dependent proliferation of TF‑1 human erythroleukemic cells. The ED50 for this effect is 0.5-2 μg/ml. |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit α (CSF2RA) is a single-pass type I membrane protein which belongs to the type I cytokine receptor family of Type 5 subfamily. The CSF2RA gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes with some of the isoforms being membrane-bound and others being soluble. CSF2RA is a low affinity receptor for granulocyte-macrophage colony-stimulating factor. CSF2RA transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4).