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Recombinant Human Cystatin C/CST3 Protein (Human Cells, His Tag)
SKU: PKSH032323-50
Recombinant Human Cystatin C/CST3 Protein (Human Cells, His Tag)
| SKU # | PKSH032323 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CST3, Cystatin-3, Cystatin-C, Gamma-trace, Neuroendocrine basic polypeptide, Post-gamma-globulin |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ser27-Ala146 |
| Accession | P01034 |
| Calculated Molecular Weight | 14.4 kDa |
| Observed Molecular Weight | 15-18 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 0.01% Tween 80, 1mM EDTA, 50% Glycerol, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Cystatin C is a member of family 2 of the cystatin superfamily. It is ubiquitous in human tissues and body fluids and mainly used as a biomarker of kidney function. Cystatin C inhibits many cysteine proteases such as papain and Cathepsins B; H; K; L and S. As an inhibitor of cysteine proteinases; Cystatin C is thought to serve an important physiological role as a local regulator of this enzyme activity. Recently; it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid (a specific type of protein deposition); such as Alzheimer's disease.