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Recombinant Human β-Defensin 4A/DEFB4A Protein
SKU: PKSH033266-50
Recombinant Human β-Defensin 4A/DEFB4A Protein
| SKU # | PKSH033266 |
| Expression Host | E.coli |
Description
| Synonyms | BD-2, Beta 2, Beta-Defensin 2, Beta-Defensin 4A, DEFB102, DEFB2, DEFB4, DEFB4A, DEFB4B, Defensin, SAP1, Skin-Antimicrobial Peptide 1, hBD-2 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Gly24-Pro64 |
| Accession | O15263 |
| Calculated Molecular Weight | 4.3 kDa |
| Observed Molecular Weight | 9 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
β-Defensin 4A is a membrane-active cationic peptide that functions in inflammation and innate immune responses. There are at least 30 β-Defensins, which are distinguished from α-Defensins by the connectivity pattern of their three intermolecular disulfide bonds. Members of the Defensin family are highly similar in protein sequence. This gene encodes Defensin, DEFB4;, which has broad-spectrum antimicrobial activity and may play an important role in innate epithelial defense. They are highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. β-Defensin 4A has low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. The 45 amino acid mature human BD3 shares 38% and 33% amino acid sequence identity with mouse and rat BD3, respectively.