Total Price: $0.00
Contact Information
Recombinant Human DTD1 Protein (His Tag)
SKU: PKSH032363-50
Recombinant Human DTD1 Protein (His Tag)
| SKU # | PKSH032363 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | C20orf88, D-tyrosyl-tRNA(Tyr) deacylase 1, DNA-unwinding element-binding protein B, DTD1, DUE-B, DUEB, HARS2, Histidyl-tRNA synthase-related |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Pro209 |
| Accession | Q8TEA8 |
| Calculated Molecular Weight | 24.5 kDa |
| Observed Molecular Weight | 30 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
| Reconstitution | Not Applicable |
Background
D-tyrosyl-tRNA(Tyr) deacylase 1(DTD1) belongs to the DTD family, and expressed in many adult and fetal tissues such as testis, ovary, spleen in adult and fetal brain. It is a nucleus and cytoplasm located protein, and is preferentially phosphorylated in cells arrested early in S phase. DTD1 is an ATPase involved in DNA replication, it may facilitate loading of CDC45 onto pre-replication complexes. The protein may hydrolyze D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr), a possible defense mechanism against a harmful effect of D-tyrosine.