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Recombinant Human dUTPase Protein
SKU: PKSH032364-50
Recombinant Human dUTPase Protein
| SKU # | PKSH032364 |
| Expression Host | E.coli |
Description
| Synonyms | DUT, Deoxyuridine 5'-Triphosphate Nucleotidohydrolase Mitochondrial, dUTP Pyrophosphatase, dUTPase |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Asn164 |
| Accession | P33316-2 |
| Calculated Molecular Weight | 17.7 kDa |
| Observed Molecular Weight | 17 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
| Reconstitution | Not Applicable |
Background
Deoxyuridine 5'-Triphosphate Nucleotidohydrolase Mitochondrial (dUTPase) belongs to the dUTPase family. dUTPase exits as a homotrimer and is involved in nucleotide metabolism. dUTPase produces dUMP; the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. The dUTPase increase in PCR product yield; length and fidelity enables further down-stream applications. These effects make dUTPase useful in PCR fidelity and yield-sensitive applications. dUTPase is specific for dUTP and is critical for the fidelity of DNA replication and repair.