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Recombinant Human DYNLL1 Protein (His Tag)
SKU: PKSH032338-50
Recombinant Human DYNLL1 Protein (His Tag)
| SKU # | PKSH032338 |
| Expression Host | E.coli |
Description
| Synonyms | 8 kDa Dynein Light Chain, DLC1, DLC8, DNCL1, DNCLC1, DYNLL1, Dynein Light Chain 1 Cytoplasmic, Dynein Light Chain LC8-Type 1, HDLC1 , PIN, Protein Inhibitor of Neuronal Nitric Oxide Synthase |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Gly89 |
| Accession | P63167 |
| Calculated Molecular Weight | 12.5 kDa |
| Observed Molecular Weight | 14 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM Histidine-HCl, 10% Trehalose, 0.05% Tween 80, pH6.0. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Human Dynein Cytoplasmic Light Chain 1 (DYNLL1) has been identified as a protein that interacts with NOS1, leading to NOS1 inhibition. NOS1 dimer is destabilized after binding DYNLL1 a conformation necessary activity, and it regulate numerous biologic processes throughits effects on nitric oxide synthase activity. DYNLL1 is widely expressed, with higher expression in testis and moderate expression in brain.