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Recombinant Human E-Cadherin/CDH1 Protein (His Tag) Purity >95%
SKU: PKSH033437-50
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Recombinant Human E-Cadherin/CDH1 Protein (His Tag) Purity >95%
| SKU # | PKSH033437 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Arc-1 , CAM 120/80, CD324, CDH1, CDHE, Cadherin-1, E-Cadherin, E-cad, E-cadherin, ECAD, LCAM, UVO |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Asp155-Ile707 |
| Accession | P12830 |
| Calculated Molecular Weight | 61.2 kDa |
| Observed Molecular Weight | 80-90 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
E-Cadherin is a classical member of the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats; a transmembrane region; and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric; breast; colorectal; thyroid; and ovarian cancers. Loss of function is thought to contribute to progression in cancer by increasing proliferation; invasion; and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells; and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. Also; E-Cadherin has a potent invasive suppressor role and it is a ligand for integrin alpha-E/beta-7.