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Recombinant Human Factor D Protein (His Tag)
SKU: PKSH033442-50
Recombinant Human Factor D Protein (His Tag)
| SKU # | PKSH033442 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | ADIPSIN, ADN, Adipsin, C3 convertase activator, CFD, Complement factor D, DF, FACTOR D, PFD, Properdin factor D |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ile26-Ala253 |
| Accession | P00746 |
| Calculated Molecular Weight | 25.8 kDa |
| Observed Molecular Weight | 28 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 2mM CaCl2, 5% Trehalose, 50% Glycerol, pH 8.5. |
| Reconstitution | Not Applicable |
Background
Complement factor D; also known as adipsin; is a member of the chymotrypsin family of serine proteases; which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement activation. Complement factor D activates a convertase (C3bBb) responsible for cleavage of the complement protein C3; which leads to the activation of terminal complement component C5-9 to form the membrane attack complex on microbial or cellular surfaces. It also functions in the regulation of systemic energy balance and physiologic and pathologic processes; including immunity and inflammation.