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Recombinant Human FAS/TNFRSF6 Protein (Fc Tag)
SKU: PKSH032413-50
Recombinant Human FAS/TNFRSF6 Protein (Fc Tag)
| SKU # | PKSH032413 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | APT1, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FAS1, FASLG receptor, TNFRSF6 and FAS, Tumor necrosis factor receptor superfamily member 6 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gln26-Asn173 |
| Accession | P25445 |
| Calculated Molecular Weight | 44.6 kDa |
| Observed Molecular Weight | 60 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
| Reconstitution | Not Applicable |
Background
FAS(TNFRSF6) is a receptor and contains three TNFR-Cys repeats and one death domain. It has been shown that FAS is involved in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. FADD (adapter molecule) recruits caspase-8 to the activated receptor, the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may play a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.