Total Price: $0.00
Contact Information
Recombinant Human Fibronectin protein (GST,His tag)
SKU: PDEH100409-100
To better serve you, we would like to discuss your specific requirement.
Please Contact Us for a quote.
Recombinant Human Fibronectin protein (GST,His tag)
| SKU # | PDEH100409 |
| Expression Host | E. coli |
Description
| Synonyms | Fibronectin;FN1;CIG;ED-B;FINC;FN;FNZ;GFND;GFND2;LETS;MSF |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Gln 32-Arg 230 |
| Accession | P02751 |
| Mol_Mass | 46.8 kDa |
| AP_Mol_Mass | 50 kDa |
| Tag | N-GST & C-His |
| Bio_Activity | Not validated for activity |
Propertie
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Fibronectin is a high-molecular weight glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Similar to integrins; fibronectin binds extracellular matrix components such as collagen; fibrin; and heparan sulfate proteoglycans. Fibronectin plays a major role in cell adhesion; growth; migration; and differentiation; and it is important for processes such as wound healing and embryonic development. Altered fibronectin expression; degradation; and organization has been associated with a number of pathologies; including cancer and fibrosis. Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer; named superfibronectin; exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth; angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.