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Recombinant Human FKBP4 Protein (His Tag)
SKU: PKSH032877-50
Recombinant Human FKBP4 Protein (His Tag)
| SKU # | PKSH032877 |
| Expression Host | E.coli |
Description
| Synonyms | 51kDa FK506-binding protein, 59kDa immunophilin, FK506-binding protein 4, FKBP4, FKBP59, HSP-binding immunophilin, Peptidyl-prolyl cis-trans isomerase FKBP4, Rotamase, immunophilin FKBP52 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Ala459 |
| Accession | Q02790 |
| Calculated Molecular Weight | 52.8 kDa |
| Observed Molecular Weight | 50-60 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 10% Glycerol, pH 8.0. |
| Reconstitution | Not Applicable |
Background
FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening.