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Recombinant Human β-Galactosidase/GLB1 Protein (His Tag)– MSE Supplies LLC

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Recombinant Human β-Galactosidase/GLB1 Protein (His Tag)

SKU: PKSH033267-50

  • $ 50995



Recombinant Human β-Galactosidase/GLB1 Protein (His Tag)

 

SKU # PKSH033267
Expression Host HEK293 Cells

 

 

Description

Synonyms Acid Beta-Galactosidase, Beta-Galactosidase, ELNR1, Elastin Receptor 1, GLB1, Lactase
Species Human
Expression Host HEK293 Cells
Sequence Leu24-Val677
Accession P16278
Calculated Molecular Weight 74.6 kDa
Observed Molecular Weight 90 kDa
Tag C-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Reconstitution Not Applicable



Background

β Galactosidase is a lysosomal β Galactosidase that hydrolyzes the terminal β Galactose from Ganglioside and Keratan sulfate. In lysosome, the mature β Galactosidase protein associates with Cathepsin A and Neuraminidase 1 to form the lysosomal multienzyme complex . An alternative splicing at the RNA level of β Galactosidase results a catalytically inactive β Galactosidase that plays an important role in vascular development. Defects of β-galactosidase (GLB1) are the cause of diseases like GM1-gangliosidosis which is a lysosomal storage disease and Morquio Syndrome B that cause patients to have abnormal elastic fibers. More than 100 mutations have been identified for β Galactosidase, which result in different residual activities of the mutant enzymes and a spectrum of symptoms in the two related diseases.