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Recombinant Human GGCT Protein (His Tag)
SKU: PKSH033273-50
Recombinant Human GGCT Protein (His Tag)
| SKU # | PKSH033273 |
| Expression Host | E.coli |
Description
| Synonyms | C7orf24, CRF21, Cytochrome C-Releasing Factor 21, GGCT, Gamma-Glutamylcyclotransferase |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Leu188 |
| Accession | O75223 |
| Calculated Molecular Weight | 23.2 kDa |
| Observed Molecular Weight | 24-30 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Human Υ-Glutamylcyclotransferase belongs to the Transferases family, specifically the Aminoacyltransferase. Gamma-Glutamylcyclotransferase catalyzes the formation of 5-Pxoproline from Gamma-Glutamyl Dipeptides. It plays an important role in Glutathione Homeostasis. Gamma-Glutamylcyclotransferase induces the release of Cytochrome C from the mitochondria resulting in the induction of apoptosis.