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Recombinant Human GGPS1 Protein (His Tag)
SKU: PKSH032484-50
Recombinant Human GGPS1 Protein (His Tag)
| SKU # | PKSH032484 |
| Expression Host | E.coli |
Description
| Synonyms | (2E,6E)-Farnesyl Diphosphate Synthase, Dimethylallyltranstransferase, Farnesyl Diphosphate Synthase, Farnesyltranstransferase, GGPP Synthase, GGPPSase, GGPS1, Geranylgeranyl Diphosphate Synthase, Geranylgeranyl Pyrophosphate Synthase, Geranyltranstransferase |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Glu300 |
| Accession | O95749 |
| Calculated Molecular Weight | 37.0 kDa |
| Observed Molecular Weight | 35 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 20% Glycerol, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Geranylgeranyl pyrophosphate synthase (GGPS1) is a member of the FPP/GGPP synthase family. GGPS1 is highly expressed in testis, heart and skeletal muscle. GGPS1 is localized in the cytoplasm and has geranylgeranyl diphosphate (GGPP) synthase activity. It catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. Other transcriptional splice variants have been found.