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Recombinant Human Glucagon/GCG Protein (His Tag)
SKU: PKSH032491-50
Recombinant Human Glucagon/GCG Protein (His Tag)
| SKU # | PKSH032491 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | GCG, GLP-1, GLP-2, GRPP, Glicentin, Glicentin-Related Polypeptide, Glucagon, Glucagon-Like Peptide 1, Glucagon-Like Peptide 2, Glucagon-like Peptide 1, Incretin Hormone, OXM, OXY, Oxyntomodulin |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Arg21-Lys180 |
| Accession | P01275 |
| Calculated Molecular Weight | 18.6 kDa |
| Observed Molecular Weight | 19 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, 1mM DTT, 50% Glycerol, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Glucagon is a secreted protein and belongs to the glucagon family. Glucagon can be cleved into 8 chains, playing an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon can regulates blood glucose by decreasing glycolysis and increasing gluconeogenesis. In addition, Glucagon is involved in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. In the glucagon antagonist, His-53 and Phe-58 are missing. This antagonist has been successfully utilized to reduce glucose concentration in vivo.