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Recombinant Human GLUT6/SLC2A6 protein (GST,His tag)
SKU: PDEH100310-100
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Recombinant Human GLUT6/SLC2A6 protein (GST,His tag)
| SKU # | PDEH100310 |
| Expression Host | E. coli |
Description
| Synonyms | Solute carrier family 2;facilitated glucose transporter member 6;SLC2A6;Glucose transporter type 6;GLUT6 |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Asn 216-Thr 289 |
| Accession | Q9UGQ3-1 |
| Mol_Mass | 33.0 kDa |
| AP_Mol_Mass | 35 kDa |
| Tag | N-GST & C-His |
| Bio_Activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
GLUT6 as a functionally uncharacterized transporter that putatively works in inflammatory responses. Inflammatory stimuli increase GLUT6 expression level, although GLUT6-knockout mice exhibit a subtle phenotype to lipopolysaccharide administration. Metabolomics and in vitro analyses show that GLUT6 functions as a glycolysis modulator in inflammatory macrophages. GLUT6 does not mediate glucose uptake and is localized on lysosomal membranes. We conclude that GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates inflammatory responses by affecting the metabolic shift in macrophages.