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Recombinant Human HBEGF Protein (His Tag)– MSE Supplies LLC

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Recombinant Human HBEGF Protein (His Tag)

SKU: PKSH032533-50

  • $ 12795



Recombinant Human HBEGF Protein (His Tag)

 

SKU # PKSH032533
Expression Host HEK293 Cells

 

 

Description

Synonyms DTR, DTS, DTSF, Diphtheria toxin receptor, HB-EGF, HEGFL, heparin-binding EGF-like growth factor, heparin-binding epidermal growth factor, pro HB-EGF, proheparin-binding EGF-like growth factor
Species Human
Expression Host HEK293 Cells
Sequence Leu20-Leu148
Accession Q99075
Calculated Molecular Weight 15.1 kDa
Observed Molecular Weight 16-27 kDa
Tag C-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

Heparin-binding EGF-like growth factor (HB-EGF) is a 12-16 kDa member of the epidermal growth factor (EGF) family. It possesses an EGF-like domain, and a heparin-binding motif. Mature HB-EGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HB-EGF shows 76% and 73% aa sequence identity with rat and mouse HB-EGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation; it is mitogenic for fibroblasts, but not endothelial cells. HB-EGF classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activity associated with ErbB4 binding appears to be limited to non-mitogenic actions, while EGFR binding induces both mitogenic and non-mitogenic activity.