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Recombinant Human HMGB2 Protein (His Tag)– MSE Supplies LLC

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Recombinant Human HMGB2 Protein (His Tag)

SKU: PKSH032545-50

  • $ 47095



Recombinant Human HMGB2 Protein (His Tag)

 

SKU # PKSH032545
Expression Host HEK293 Cells

 

 

Description

Synonyms HMG-2, HMG2, HMGB2, High Mobility Group Protein 2, High Mobility Group Protein B2
Species Human
Expression Host HEK293 Cells
Sequence Gly2-Glu209
Accession P26583
Calculated Molecular Weight 25.1 kDa
Observed Molecular Weight 28 kDa
Tag C-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, pH 8.0.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

High Mobility Group Protein B2 (HMGB2) belongs to the non-histone chromosomal high-mobility group protein family. Members of this family are chromatin-associated and widely spread in the nucleus of higher eukaryotic cells. HMGB2 contains 2 HMG box DNA-binding domains. It is associated with chromatin and has the ability to bend DNA, preferentially single-stranded DNA. It is shown that HMGB2 is able to efficiently bend DNA and form DNA circles. In addition, HMGB2 is involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.