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Recombinant Human IFNα2b/IFNA2 Protein
SKU: PKSH033640-50
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Recombinant Human IFNα2b/IFNA2 Protein
| SKU # | PKSH033640 |
| Expression Host | E.coli |
Description
| Synonyms | IFN-Alpha-2, IFN-alpha 2b, IFNA2, Interferon Alpha-2, Interferon Alpha-A, LeIF A |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Cys24-Glu188 |
| Accession | P01563 |
| Calculated Molecular Weight | 19.4 kDa |
| Observed Molecular Weight | 17 kDa |
| Tag | None |
| Bio-activity | Measured in antiviral assay using A549 human lung cancer cells infected with vesicular stomatitisvirus (VSV) The ED50 for this effect is 5 ng/mL. |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
At least 23 different variants of IFN-α are known. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-α subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-α subtypes differ in their sequences by only one or two positions. Naturally occurring variants also include proteins that are truncated by 10 amino acids at the carboxyl-terminal end.