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Recombinant Human IGF2BP2 Protein (His Tag, N-T7 Tag)
SKU: PKSH032557-50
Recombinant Human IGF2BP2 Protein (His Tag, N-T7 Tag)
| SKU # | PKSH032557 |
| Expression Host | E.coli |
Description
| Synonyms | Hepatocellular Carcinoma Autoantigen p62, IGF-II mRNA-Binding Protein 2, IGF2 mRNA-Binding Protein 2, IGF2BP2, IMP-2, IMP2, Insulin-Like Growth Factor 2 mRNA-Binding Protein 2, VICKZ Family Member 2, VICKZ2 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Thr 220 |
| Accession | Q9Y6M1 |
| Calculated Molecular Weight | 27.2 kDa |
| Observed Molecular Weight | 43 kDa |
| Tag | N-T7 & C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 (IGFBP2) belongs to the RRM IMP/VICKZ family. IGFBP2 is a cytoplasmic protein and contains four KH domains and two RRM (RNA recognition motif) domains. IGF2BP2 binds to the 5'-UTR of the Insulin-Like Growth Factor 2 (IGF2) mRNA. This binding is isoform-specific. IGF2BP2 may regulate translation of target mRNAs. Genetic variation at the IGF2BP2 gene has been associated with type 2 diabetes (T2D) by genome-wide association studies and by replication analyses.