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Recombinant Human IL-1R9/IL1RAPL2 Protein (His Tag)(Active)
SKU: PKSH031826-100
Recombinant Human IL-1R9/IL1RAPL2 Protein (His Tag)(Active)
| SKU # | PKSH031826 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | IL1R, IL-1R, TIGIRR, IL1RAPL2, IL-1R9, IL1R9, IL1RAPL-2, TIGIRR-1, IL 1 RAPL 2, IL 1 receptor accessory protein like 2, IL 1R 9, IL 1R9, IL 1RAPL 2, IL1 receptor accessory protein like 2, IL-1 receptor accessory protein-like 2, IL-1R-9, IL1RAPL 2, IL-1RAPL-2, IL-1-RAPL-2, IL1RAPL2 related protein, IL1RAPL-2-related protein, Interleukin 1 receptor 9, Interleukin 1 receptor accessory protein like 2, Interleukin-1 receptor 9, IRPL2_HUMAN, Three immunoglobulin domain containing IL1 receptor related 1, Three immunoglobulin domain-containing IL-1 receptor-related 1, TIGIRR 1, TIGIRR1, X linked interleukin 1 receptor accessory protein like 2, X-linked interleukin-1 receptor accessory protein-like 2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Glu 356 |
| Accession | NP_059112.1 |
| Calculated Molecular Weight | 40.7 kDa |
| Observed Molecular Weight | 50-55 kDa |
| Tag | C-His |
| Bio-activity | Measured by its ability to bind biotinylated human IL1α in functional ELISA. |
Properties
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
X-linked interleukin-1 receptor accessory protein-like 2 (IL1RAPL2) or Interleukin-1 receptor 9 (IL-1R9) is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins. IL-1R9/IL1RAPL2 shows restricted expression in fetal brain and is highly homologous to IL1RAPL; which is reportedly involved in nonsyndromic X-linked mental retardation. IL-1R9/IL1RAPL2 is highly homologous to IL-1R8. Both forms have no known ligands and receptor are found in the fetal brain. IL-1R9/IL1RAPL2 may function as a negative receptor. Both IL1RAPL1 and IL1RAPL2 have novel C-terminal sequences not present in other related proteins. IL-1R9/IL1RAPL2 may be strong candidates for X-linked non-syndromic mental retardation loci; and that molecules resembling IL-1 and IL-18 play a role in the development or function of the central nervous system.