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Recombinant Human IL-2RB/CD122 Protein (Fc Tag)(Active)
SKU: PKSH032572-50
Recombinant Human IL-2RB/CD122 Protein (Fc Tag)(Active)
| SKU # | PKSH032572 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | P70, IL2RB, CD122, IL15RB, P70-75, IL-2Rβ, p75, IL-2RB, Interleukin-2 receptor subunit beta, IL-2 receptor subunit beta, IL-2R subunit beta, High affinity IL-2 receptor subunit beta, Interleukin-15 receptor subunit beta, p70-75 (p75), IL-2R&, beta, CD122 antigen, High affinity IL 2 receptor beta subunit, High affinity IL 2 receptor subunit beta, IL2 receptor, Interleukin 2 receptor beta, interleukin 2 receptor subunit beta, P70 75, P7075 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ala27-Asp239 |
| Accession | P14784 |
| Calculated Molecular Weight | 51.7 kDa |
| Observed Molecular Weight | 60-80 kDa |
| Tag | C-Fc |
| Bio-activity | Loaded Biotinylated Human IL-2-His-Avi on SA Biosensor, can bind Human IL-2RB-Fc with an affinity constant of 12.62nM as determined in BLI assay. |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Human IL-2RB; also known asinterleukin-2 receptor subunit beta;is the receptor for interleukin-2. IL2 receptor complex is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2 receptor complex has three forms with respect to ability to bind IL2. IL-2RB is belonged to a type I membrane protein;and has a 26 residue signal peptide; a 214 residue extracellular region; a 25 residue transmembrane region and a 286 residue cytoplasmic domain. IL-2RB is the subunit critical for receptor-mediated signaling via physically or functionally coupling to other signaling molecules; such as the Jak-STAT and Src-family protein tyrosine kinase although it lacks apparent catalytic motifs.