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Recombinant Human IL17RA Protein (Fc Tag)(Active)
SKU: PKSH033395-50
Recombinant Human IL17RA Protein (Fc Tag)(Active)
| SKU # | PKSH033395 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | IMD, MGC, CTLA, CANDF, CDw, IL17RA, CANDF5, CD217, CDw217, IL-17RA, IL17R, IMD51, hIL-17R, CD127, CD217 antigen, CDW127, CTLA8, HIL 17R, hIL17R, I17RA, IL 17 receptor, IL 17 receptor A, IL 17RA, IL17, IL-17 R alpha, IL-17 receptor A, IL17A receptor, IL-17R, IL17R-A, IL17-RA, IL-17R-alpha, IL7RA, ILRA, Interleukin 17 receptor A, Interleukin-17 receptor A, MGC10262, CDw217, Interleukin-17 receptor A |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Leu33-Trp320 |
| Accession | Q96F46 |
| Calculated Molecular Weight | 60.6 kDa |
| Observed Molecular Weight | 90-120 kDa |
| Tag | C-Fc |
| Bio-activity | Immobilized Human IL-17RA-Fc at 2μg/ml (100 μl/well)can bind Anti-Human IL-17RA mAb.The ED50 of Anti-Human IL-17RA mAb is 13.50 ng/ml. |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors; this receptor likely has a multimeric structure.