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Recombinant Human IL18BP Protein (Fc Tag)
SKU: PKSH032626-50
Recombinant Human IL18BP Protein (Fc Tag)
| SKU # | PKSH032626 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | I18BP, IL18 BP, IL18 BPa, IL-18BP, IL18BPa, Interleukin 18 binding protein, Interleukin-18-binding protein, MC51L 53L 54L homolog gene product, Tadekinig alfa, Tadekinig-alfa, Tadekinig-alfa and IL18BP, IL18BP |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Thr31-Gly194 |
| Accession | O95998 |
| Calculated Molecular Weight | 44.8 kDa |
| Observed Molecular Weight | 60-75 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-18-binding protein, also known as Tadekinig-alfa and IL18BP, contains 1 Ig-like C2-type domain. IL18BP is constitutively expressed and secreted in mononuclear cells. IL18BP functions as an IL18 inhibitor. IL18BP binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. It has been shown that IL18BP may be a promising molecular approach to inhibit neointimal hyperplasia and arteriosclerosis progression following coronary and peripheral angioplasty.