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Recombinant Human IL1F6/IL36A Protein (His Tag)
SKU: PKSH031509-20
Recombinant Human IL1F6/IL36A Protein (His Tag)
| SKU # | PKSH031509 |
| Expression Host | E.coli |
Description
| Synonyms | FIL, IL1F, Interleukin-1 Family Member, IL-1F, IL36A, FIL1, FIL1(EPSILON), FIL1E, IL-1F6, IL1(EPSILON), IL1F6, FIL1 Epsilon, IL-1 Epsilon, Interleukin-1 Epsilon, Interleukin-1 Family Member 6, Interleukin-36 Alpha, IL1E, IL 1 epsilon, IL 1F6, IL 1H1, IL1RP2, Interleukin 1 epsilon, Interleukin 1 family member 6, Interleukin 1 family member 6 (epsilon), Interleukin 36 alpha, MGC129552, MGC129553, MGC151479, MGC151481, OTTMUSP00000012798, RP23-176J12.4 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Lys 6-Phe158 |
| Accession | Q9UHA7 |
| Calculated Molecular Weight | 19.2 kDa |
| Observed Molecular Weight | 20 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 99 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-1 family member 6 (IL-1F6); also known as interleukin 36; alpha (IL36A); is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. It has been reported that IL-1F6 and IL-1F8; in addition to IL-1F9; activate the pathway leading to NF-kappaB in an IL-1Rrp2-dependent manner in Jurkat cells as well as in multiple other human and mouse cell lines. Activation of the pathway leading to NF-kappaB by IL-1F6 and IL-1F8 follows a similar time course to activation by IL-1beta; suggesting that signaling by the novel family members occurs through a direct mechanism. In a mammary epithelial cell line; NCI/ADR-RES; which naturally expresses IL-1Rrp2; all three cytokines signal without further receptor transfection. IL-1Rrp2 antibodies block activation of the pathway leading to NF-kappaB by IL-1F6; IL-1F8; and IL-1F9 in both Jurkat and NCI/ADR-RES cells. Thus IL-1F6; IL-1F8; and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP.