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Recombinant Human ILT4/LILRB2 Protein (His tag)
SKU: PDMH100140-100
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Recombinant Human ILT4/LILRB2 Protein (His tag)
| SKU # | PDMH100140 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD85 Antigen-Like Family Member D, CD85d, ILT-4, Immunoglobulin-Like Transcript 4, L, LIR-2, Leukocyte Immunoglobulin-Like Receptor 2, Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2, MIR-10, Monocyte/Macrophage Immunoglobulin-Like Receptor 10 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met1-Val461 |
| Accession | Q8N423 |
| Calculated Molecular Weight | 50.6 kDa |
| Observed Molecular Weight | 75 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95% as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
Background
Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. LIR-2 binds to Classical MHCI proteins. Ligation of LIR-2 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. LIR-2 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo.